Informatics Publishing Limited

V. K. Goyal ¹, A. S. Kulkarni ¹, P. N. Dhabale ¹

Affiliations
1 Government College of Pharmacy, Vidyanagar, Karad-415124, Dist Satara, IN

Abstract

Two sensitive, simple, rapid, accurate and precise UV spectrophotometric methods for simultaneous estimation of Rosiglitazone Maleate (RSGN) and Gliclazide (GLZ) in two component solid dosage forms have been developed. These methods employ the application of simultaneous equation and the absorbance ratio (Q-analysis). A Shimadzu 1700 U.V visible spectrophotometer with 1cm matched quartz cells, and 0.1 N NaOH as solvent were employed in the both methods. Simultaneous equation method involves the formation and solving of simultaneous equations at two wavelengths 245 nm (λ_max of RSGN) and 226 nm (λ_max of GLZ). Q analysis method is based on the determination of absorbance ratio at two selected wavelengths, one being the isoabsorptive point for the two drugs (235 nm) and other being the absorption maxima of RSGN. Both developed methods obeyed the Beer’s law in the concentration range of 4-32 μg/ml for RSGN and 5-40 μg/ml for GLZ. The precision and accuracy of method were confirmed by repeatability and by recovery studies. Both methods were validated statistically. The method shows good repeatability and recovery with % RSD is less than 2. The method can be successfully employed for the simultaneous estimation of RSGN and GLZ in laboratory prepared mixtures and in commercial tablet preparation.

Keywords

Rosiglitzone, Gliclazide, U.V., Simultaneous Estimation.

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K. K. Yadav ¹, N. Chouhan ², R. Thubstan ², S. Norlha ², J. Hariharan ², C. Borwankar ², P. Chandra ², V. K. Dhar ¹, N. Mankuzhyil ², S. Godambe ², M. Sharma ², K. Venugopal ², K. K. Singh ¹, N. Bhatt ², S. Bhattacharyya ¹, K. Chanchalani ², M. P. Das ², B. Ghosal ², S. Godiyal ², M. Khurana ², S. V. Kotwal ², M. K. Koul ², N. Kumar ², C. P. Kushwaha ², K. Nand ², A. Pathania ², S. Sahayanathan ¹, D. Sarkar ², A. Tolamati ², R. Koul ³, R. C. Rannot ⁴, A. K. Tickoo ⁵, V. R. Chitnis ⁶, A. Behere ⁷, S. Padmini ⁷, A. Manna ⁷, S. Joy ⁷, P. M. Nair ⁷, K. P. Jha ⁷, S. Moitra ⁷, S. Neema ⁷, S. Srivastava ⁷, M. Punna ⁷, S. Mohanan ⁷, S. S. Sikder ⁷, A. Jain ⁷, S. Banerjee ⁷, Krati ⁷, J. Deshpande ⁷, V. Sanadhya ⁸, G. Andrew ⁸, M. B. Patil ⁸, V. K. Goyal ⁸, N. Gupta ⁸, H. Balakrishna ⁸, A. Agrawal ⁸, S. P. Srivastava ⁹, K. N. Karn ⁹, P. I. Hadgali ⁹, S. Bhatt ⁹, V. K. Mishra ⁹, P. K. Biswas ⁹, R. K Gupta ⁹, A. Kumar ⁹, S. G. Thul ⁹, R. Kalmady ¹⁰, D. D. Sonvane ¹⁰, V. Kumar ¹⁰, U. K. Gaur ¹⁰, J. Chattopadhyay ¹¹, S. K. Gupta ¹¹, A. R. Kiran ¹¹, Y. Parulekar ¹¹, M. K. Agrawal ¹¹, R. M. Parmar ¹¹, G. R. Reddy ¹², Y. S. Mayya ¹³, C. K. Pithawa ¹⁴

Affiliations
1 Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India; Homi Bhabha National Institute, Mumbai 400 085, India, IN
2 Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
3 Formerly at Astrophysical Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
4 Raja Ramanna Fellow at Astrophysical Sciences Division, Mumbai 400 085, India, IN
5 Deceased, IN
6 Department of High Energy Physics, Tata Institute of Fundamental Research, Mumbai 400 005, India, IN
7 Electronics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
8 Control and Instrumentation Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
9 Center for Design and Manufacture, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
10 Computer Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
11 Reactor Safety Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
12 Formerly at Reactor Safety Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
13 Formerly at Reactor Control Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN
14 Formerly at Electronics Division, Bhabha Atomic Research Centre, Mumbai 400 085, India, IN

Abstract

The MACE telescope has recently been commissioned at Hanle, Ladakh, India. It had its first light in April 2021 with a successful detection of very high energy gamma-ray photons from the standard candle Crab Nebula. Equipped with a large light collector of 21 m diameter and situated at an altitude of ~4.3 km amsl, the MACE telescope is expected to explore the mysteries of the non-thermal Universe in the energy range above 20 GeV with very high sensitivity. It can also play an important role in carrying out multi-messenger astronomy in India.

Keywords

Gamma-ray astronomy, high energy radiative processes, non-thermal Universe, telescope.

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